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No effect of polymorphisms in catechol-O-methyltransferase was discovered being associated with postoperative oxycodone consumption. The pharmacodynamics of oxycodone is mostly dependent on polymorphic enzymes CYP2D6 and CP3A.Using hydrocodone or oxycodone with antidepressants can cause a harmful buildup in the brain chemical serotonin.et al. Intra